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For quantitative studies, theinvestigator must develop a design for obtaining empirical data about the relationship ofthe independent and dependent variables of interest.

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This mayexplain situations where removal of T cells, based on the Treg phenotype (by anti-CTLAantibodies) during an anti-tumor T cell immune response, results in an increase instead of adecrease in tumor growth.

The ability of epithe-lia to create a diffusion barrier is controlled by two distinctpathways for transport of substances across the epithelia(Fig.